ヒトゲノム多様性研究室


大橋 順(Jun Ohashi)

略歴

2014年10月 東京大学大学院理学系研究科生物科学専攻准教授
2011年10月 筑波大学医学医療系准教授(組織改編による名称変更)
2008年  7月 筑波大学大学院人間総合科学研究科社会環境医学専攻准教授
2007年  4月 東京大学大学院医学系研究科人類遺伝学分野助教
2003年  5月 米国コーネル大学分子生物学遺伝学研究分野文部科学省在外研究員
1997年10月 東京大学大学院医学系研究科人類遺伝学分野助手
1997年10月 東京大学大学院医学系研究科国際保健学専攻研究生
1997年  9月 東京大学大学院医学系研究科国際保健学専攻博士課程単位取得済退学
1995年  3月 東京大学大学院医学系研究科国際保健学専攻修士課程修了
1993年  3月 東京大学医学部保健学科卒業



  研究業績 


英文原著論文(大橋順がcorresponding authorの論文には*を付す)


2017


183) Nakayama K, Ohashi J, Watanabe K, Munkhtulga L, Iwamoto S. Evidence for very recent positive selection in  Mongolians. Molecular Biology and Evolution (in press)


*182) Naka I, Furusawa T, Kimura R, Natsuhara K, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, Inaoka T, Matsumura Y,Ohtsuka R, Ohashi J. A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic  populations. Journal of Human Genetics (in press)


*181) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa M, Ishida T, Ohtsuka R, Ohashi J (2017)Polymorphisms Associated with a Tropical Climate and Root Crop Diet Induce Susceptibility to Metabolic and Cardiovascular  Diseases in Solomon Islands. PLoS ONE 12: e0172676.


180) Yasukochi Y, Naka I, Patarapotikul J, Hananantachai H, Ohashi J (2017) Evolution of Fseg/Cseg dimorphism in region IIIof Plasmodium falciparum eba-175 gene. Infection, Genetics and Evolution 49: 251-255.


179) Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Ohyagi Y, Kawamoto R, KoharaK, Miki T, Osawa H (2017) Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at -420 on Plasma Resistin:Genotype and DNA Methylation. The Journal of Clinical Endocrinology & Metabolism 102: 884-892.


178) Yasukochi Y, Ohashi J (2017) Elucidating the origin of HLA-B*73 allelic lineage: Did modern humans benefit by archaicintrogression? Immunogenetics 69: 63-67.


177) Kamori D, Hasan Z, Ohashi J, Kawana-Tachikawa A, Gatanaga H, Oka S, Ueno T (2017) Identification of two uniquenaturally occurring Vpr sequence polymorphisms associated with clinical parameters in HIV-1 chronic infection. Journal ofMedical Virology 89: 123-129.

2016


176) Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, TanigawaT, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H (2016) A genome-wide association study of plasma resistin levelsidentified rs1423096 and rs10401670 as possible functional variants in the Japanese population. Physiological Genomics 48:874?881.


*175) Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Wichukchinda N, Sawanpanyalert P, Patarapotikul P, Tsuchiya N,Ohashi J (2016) Association of BAK1 single nucleotide polymorphism with a risk for dengue hemorrhagic fever. BMC MedicalGenetics 17: 43.


*174) Ohashi J, Naka I, Hananantachai H, Patarapotikul J (2016) Association of PECAM1/CD31 polymorphisms with cerebralmalaria. International Journal of Molecular Epidemiology and Genetics 7: 87-94.

173) Nishida N, Ohashi J, Khor SS, Sugiyama M, Tsuchiura T, Sawai H, Hino K, Honda M, Kaneko S, Yatsuhashi H, YokosukaO, Koike K, Kurosaki M, Izumi N, Korenaga M, Kang JH, Tanaka E, Taketomi A, Eguchi Y, Sakamoto N, Yamamoto K, TamoriA, Sakaida I, Hige S, Itoh Y, Mochida S, Mita E, Takikawa Y, Ide T, Hiasa Y, Kojima H, Yamamoto K, Nakamura M, Saji H,Sasazuki T, Kanto T, Tokunaga K, Mizokami M (2016) Understanding of HLA-conferred susceptibility to chronic hepatitis Binfection requires HLA genotyping-based association analysis. Scientific Reports 6: 24767.

172) Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja C, Win Z, Htike W, Marma A, Dysoley L, Ndounga M,Dzodzomenyo M, Akhwale W, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira M, Endo H, Ohashi J (2016) Littlepolymorphism at the K13 propeller locus in worldwide Plasmodium falciparum populations prior to the introduction ofartemisinin combination therapies. Antimicrobial Agents and Chemotherapy 60: 3340-3347.

171) Liu X, Homma A, Sayadi J, Yang S, Ohashi J, Takumi T (2016) Sequence features associated with the cleavage efficiencyof CRISPR/Cas9 system. Scientific Reports 6: 19675.

170) Hamada J, Onuma H, Ochi F, Hirai H, Takemoto K, Miyoshi A, Matsushita M, Kadota Y, Ohashi J, Kawamura R, Takata Y,Nishida W, Hashida S, Ishii E, Osawa H. Endoplasmic reticulum stress induced by tunicamycin increases resistin mRNAthrough the PERK-ATF4-CHOP pathway in THP-1 human monocytes. Journal of Diabetes Investigation (in press)

2015


169) Nishida N, Ohashi J, Sugiyama M, Tsuchiura T, Yamamoto K, Hino K, Honda M, Kaneko S, Yatsuhashi H, Koike K,Yokosuka O, Tanaka E, Taketomi A, Kurosaki M, Izumi N, Sakamoto N, Eguchi Y, Sasazuki T, Tokunaga K, Mizokami M (2015)Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese. Tissue Antigens 86: 406-412.


168) Yasukochi Y, Naka I, Patarapotikul J, Hananantachai H, Ohashi J (2015) Genetic evidence for contribution of humandispersal to the genetic diversity of EBA-175 in Plasmodium falciparum. Malaria Journal 14: 293.


167) Miyadera H, Ohashi J, Lernmark A, Kitamura T, Tokunaga K (2015) Cell-surface MHC density profiling identifiestheprotein instability of autoimmunity-associated HLA. The Journal of Clinical Investigation 125: 275-291.


2014


 
166) Nishida W, Nagata M, Imagawa A, Hanafusa T, Ohashi J, Takahashi K, Suehiro T, Yamada Y, Chujo D, Kawasaki E,Kawamura R, Onuma H, Osawa H, Makino H (2014) Insulin administration may trigger type 1 diabetes inJapanesetype2diabetes patients with type 1 diabetes high-risk HLA class II and the insulin gene VNTR gentype. The JournalofClinicalEndocrinology   & Metabolism 99: E1793-E1797.


165) Fujita A, Ishibe N, Yoshihara T, Ohashi J, Makino H, Ikeda M, Setoguchi H (2014) Rapid reversal of neuromuscular  blockade by sugammadex after continuous infusion of rocuronium in patients with liver dysfunctionundergoinghepaticsurgery.Acta Anaesthesiologica Taiwanica 52: 54-58.


*164) Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Chanama S, Wichukchinda N, Sawanpanyalert P, Patarapotikul P,Tsuchiya N, Ohashi J (2014) A replication study confirms the association of GWAS-identified SNPs at MICB and PLCE1 in Thai  patients with dengue shock syndrome. BMC Medical Genetics 15: 58.


*163) Naka I, Patarapotikul J, Hananantachai H, Imai H, Ohashi J (2014) Association of the endothelial protein C receptor(PROCR) rs867186-G allele with protection from severe malaria. Malaria Journal 13:105  doi:10.1186/1475-2875-13-105.


*162) Naka I, Patarapotikul J, Hananantachai H, Ohashi J. Lack of Association between BSG Polymorphisms and Cerebral  Malaria. Japanese Journal of Infectious Diseases 67(6):432-5.


161) Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu S, Palacpac NMQ, Hisaeda H, Matsuoka H, Kawai S, Endo H,YasunagaT, Ohashi J, Mita T, Horii T, Furusawa M, Tanabe K. Generation of rodent malaria parasites with ahighmutationrateby destructing proofreading activity of DNA polymerase δ. DNA Research (4):439-46.


*160) Ohashi J, Suzuki Y, Naka I, Hananantachai H, Patarapotikul J (2014) Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum in Thailand. PLoS ONE 9: e90522.


159) Sa-Ngasang A, Ohashi J, Naka I, Anantapreecha S, Sawanpanyalert P, Patarapotikul J (2014) Association of IL1B -31C/Tand  IL1RA variable number of an 86-bp tandem repeat with Dengue Shock Syndrome in Thailand. The Journal of InfectiousDiseases 210:138-145.


158) Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH,HanKH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JH, Hige S, Ide T, Yamamoto K, Sakaida I, Murawaki Y,ItohY, Tamori A, Orito E, Hiasa Y, Honda M, Kaneko S, Mita E, Suzuki K, Hino K, Tanaka E, Mochida S,WatanabeM, Eguchi Y,Masaki N, Murata K, Korenaga M, Mawatari Y, Ohashi J, Kawashima M, Tokunaga K, Mizokami M.(2014)Newsusceptibilityandresistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.PLoS ONE: e86449.


157) Shiraishi S, Miyao S, Kikuchi N, Ochi K, Sato E, Ohashi J, Kawamura R, Osawa H, Makino H. (2014)Effectsofcarbohydrate counting on glycemic control and quality of life in patients with type 1 diabetes: a pilot study.Diabetology International  34(4):823-7.


156) Mita T, Ohashi J, Nakamura M, Endo H, Tanabe K (2014) Ordered accumulation of mutationsconferringresistancetosulfadoxine-pyrimethamine in the Plasmodium falciparum parasite. The Journal of Infectious Diseases209: 130-139.


2013



*155) Naka I, Ohashi J, Kimura R, Inaoka T, Matsumura Y (2013) Association of ADRB2 polymorphism withtriglyceridelevelsin Tongans. Lipids in Health and Disease 12: 110.


154) Furusawa T,  Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y,AtakaY, Ohtsuka R, Ohashi J (2013) Hypertension Susceptibility Gene Prevalence in the Pacific Islandsand Associations withHypertension in Melanesia. Journal of Human Genetics 58:142-149.


153) Noguchi S, Hijikata M, Hamano E, Matsushita I, Ito H, Ohashi J, Nagase T, Keicho N (2013) MxA transcripts with distinctfirst exons and modulation of gene expression levels by single-nucleotide polymorphisms in human bronchial epithelialcells.Immunogenetics 65: 107-114.


*152) Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M,Ataka Y, Ishida T, InaokaT, Iwamoto S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J (2013) A functional SNP upstream ofthe beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations. International Journal ofObesity 37(9):1204-10.


151) Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Kawamoto R, Kohara K, Miki T,Osawa H (2013) Plasma resistin is associated with single nucleotide polymorphisms of a possible resistin receptor,thedecoringene, in the general Japanese population. Diabetes 62: 649-652.



2012



150) Japanese Archipelago Human Population Genetics Consortium (Consortium members: Jinam T, Nishida N, Hirai M,Kawamura S, Oota H, Umetsu K, Kimura R, Ohashi J, Tajima A, Yamamoto T, Tanabe H, Mano S, Suto Y, Kaname T,NaritomiK, Yanagi K, Niikawa N, Omoto K, Tokunaga K, Saitou N (2012) The history of human populations in the JapaneseArchipelago inferred from genome-wide SNP data with aspecial reference to the Ainuand the Ryukyuan populations. Journal ofHuman Genetics 57: 787-795.


*149) Kawashima M, Ohashi J, Nishida N, Tokunaga K (2012) Evolutionary analysis of classical HLA class I and II genessuggests that recent positive selection acted on DPB1*04:01 in Japanese population. PLoS One7:e46806.


148) Onuma H, Tohyama M, Imagawa A, Hanafusa T, Kobayashi T, Kano Y, Ohashi J, Hashimoto K, Osawa H, Makino H(2012) High frequency of HLA B62 in fulminant type 1 diabetes with the drug-induced hypersensitivity syndrome.TheJournalof Clinical Endocrinology & Metabolism 97: E2277-E2281.


147) Furukawa H, Oka S, Shimada K, Sugii S, Ohashi J, Matsui T, Ikenaka T, Nakayama H, Hashimoto A, Takaoka H,ArinumaY, Okazaki Y, Futami H, Komiya A, Fukui N, Nakamura T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S (2012)Association of Human Leukocyte Antigen with Interstitial Lung Disease in Rheumatoid Arthritis: A Protective Role for SharedEpitope. PLoSOne 7: e33133.


146) Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A, Takanashi M, Satake M, Nakajima K, Arase H,Tokunaga K, Patarapotikul J, Yabe T (2012) Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria andimplications for co-evolution of KIR and HLA. PLoS Pathogens 8: e1002565.


*145) Naka I, Ohashi J, Kimura R, Furusawa T, Yamauchi T, Nakazawa M, Natsuhara K, Ataka Y, Nishida N, Ishida T, InaokaT,Matsumura Y, Ohtsuka R (2012) DRD4 VNTR polymorphism in Oceanic populations. Anthropological Science 120: 151-155.


144) Hijikata M, Shojima J, Matsushita I, Tokunaga K, Ohashi J, Hang NTL, Horie T, Sakurada S, Hoang NP, Thuong PH,LienLT, Keicho N (2012) Association of IFNGR2 gene polymorphisms with pulmonary tuberculosis among the Vietnamese.Human Genetics 131: 675-682.



2011



143) Kawamura R, Tabara Y, Onuma H, Kawamoto R, Ohashi J, Takata Y, Nishida W, Katsuhiko Kohara K, Makino H, Miki T,Osawa H (2011) A single-nucleotide polymorphism in the human THADA gene is associated with circulating resistin in thegeneral Japanese population. Diabetology International 2: 190-196.


*142) Kraisin S, Naka I, Patarapotikul J, Nantakomol D, Nuchnoi P, Hananantachai H, Tsuchiya N, Ohashi J (2011)Associationof ADAMTS13 polymorphism with cerebral malaria. Malaria Journal 10: 366.


141) Mita T, Venkatesan M, Ohashi J, Culleton R, Takahashi N, Tsukahara T, Ndounga M, Dysoley L, Endo H, Hombhanje F,Ferreira MU, Plowe CV, Tanabe K (2011) Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles inPlasmodium falciparum populations. The Journal of Infectious Diseases 204: 1980-1988.


*140) Naka I, Nishida N, Ohashi J (2011) No evidence for strong recent positive selection favoring the 7 repeat allele of VNTRin the DRD4 gene. PLoS One 6: e24410.


139) Koga M, Kawasaki A, Ito I, Furuya T, Ohashi J, Kyogoku C, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Takasaki Y,Hashimoto H, Sumida T, Tsuchiya N (2011) Cumulative association of eight susceptibility genes with systemic lupuserythematosus in a Japanese female population. Journal of Human Genetics 56:503-507.


138) Myles S, Lea RA, Ohashi J, Chambers GK, Weiss JG, Hardouin E, Engelken J, Macartney-Coxson DP, Eccles DA, Naka I,Kimura R, Inaoka T, Matsumura Y, Stoneking M (2011) Testing the thrifty gene hypothesis: the Gly482Ser variant inPPARGC1 Aisassociated with BMI in Tongans. BMC Medical Genetics 12: 10.


137) Hijikata M, Matsushita I, Tanaka G, Tsuchiya T, Ito H, Tokunaga K, Ohashi J, Homma S, Kobashi Y, Taguchi Y, Azuma A,Kudoh S, Keicho N (2011) Molecular cloning of two novel mucin-like genes in the disease-susceptibilitylocusfordiffusepanbronchiolitis. Human Genetics 129: 117-128.


136) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Nishida N, Eddie R, Ohtsuka R, OhashiJ(2011) The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: Focusongeneticfactorsand urbanization. American Journal of Human Biology 23: 435-444.


*135) Ohashi J, Naka I, Tsuchiya N (2011) The impact of natural selection on an ABCC11 SNP determining earwax type.Molecular Biology and Evolution 28: 849-857.



2010



134) Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi M, Ohashi J, Graham RR, Matsuta K,BehrensTW, Tohma S, Takasaki Y, Hashimoto H, Sumida Tand, Tsuchiya N (2010) Association of TNIP1withsystemiclupuserythematosus in a Japanese population: a case-control association study. Arthritis Research &Therapy 12:R174.


133) Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H,Osawa H (2010) The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes,reducedfastingplasmaglucose levels, increased triglycerides levels, and lower HOMA-IR in Japanese population. Journal ofHuman Genetics 55: 600-604.


132) Ridruechai C, Mahasirimongkol S, Phromjai J, Yanai H, Nishida N, Matsushita I, Ohashi J, Yamada N, Moolphate S,Summanapan S, Chuchottaworn C, Manosuthi W, Kantipong P, Kanitvittaya S, Sawanpanyalert P, Keicho N, Khusmith S,Tokunaga K. (2010) Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis.GenesandImmunity 11: 416-422.


131) Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K,Miki T, Makino H, Osawa H (2010) A at single nucleotide polymorphism-358 is required for G at -420 toconferthehighestplasma resistin in the general Japanese population. PLoS ONE 5(3): e9718.


130) Osawa H, Tabara Y, Ohashi J, Kawamura R, Onuma H, Makino H (2010) Is rs34861192 or rs1862513amorepromisingvariant for determining plasma resistin in an aged Japanese population? Diabetologia 53: 795-797.


129) Ito I, Kawaguchi Y, Kawasaki A, Hasegawa M, Ohashi J, Kawamoto M, Fujimoto M, Takehara K, Sato S, Hara M,TsuchiyaN(2010) Association of FAM167A (C8orf13) - BLK region with systemic sclerosis. Arthritis & Rheumatism 62: 890-895.


128) Nantakomol D, Chanprasert S, Soogarun S, Ohashi J, Nuchnoi P (2010) Affordable technology forenumerationoftheabsolute CD4 T-lymphocyte count by cell bead assay. Lab Medicine 41: 423-428.


*127) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ataka Y,Nishida N, Tsuchiya N, Ohtsuka R, Ohashi J (2010) The Q223R polymorphism in LEPR is associated withobesityinPacificIslanders. Human Genetics 127: 287-294.


126) Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M,SomeyaT, Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S, Naka I, Ohashi J,Kakita A,Takahashi H, Nawa H, Arinami T (2010) Brain Cannabinoid CB2 Receptor in Schizophrenia. Biological Psychiatry 67:974-982.


2009



125) HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC,Chaurasia A, Chen CH, Chen J, Chen YT, Chu J, Cutiongco-de la Paz EM, De Ungria MC, Delfin FC, Edo J, Fuchareon S,GhangH, Gojobori T, Han J, Ho SF, Hoh BP, Huang W, Inoko H, Jha P, Jinam TA, Jin L, Jung J, Kangwanpong D,KampuansaiJ,Kennedy GC, Khurana P, Kim HL, Kim K, Kim S, Kim WY, Kimm K, Kimura R, Koike T, Kulawonganunchai S,Kumar V, LaiPS,Lee JY, Lee S, Liu ET, Majumder PP, Mandapati KK, Marzuki S, Mitchell W, Mukerji M, Naritomi K, NgamphiwC, Niikawa N,Nishida N, Oh B, Oh S, Ohashi J, Oka A, Ong R, Padilla CD, Palittapongarnpim P, Perdigon HB, Phipps ME, PngE, Sakaki Y,Salvador JM, Sandraling Y, Scaria V, Seielstad M, Sidek MR, Sinha A, Srikummool M, Sudoyo H, Sugano S, SuryadiH,SuzukiY,Tabbada KA, Tan A, Tokunaga K, Tongsima S, Villamor LP, Wang E, Wang Y, Wang H, Wu JY, Xiao H, Xu S, YangJO,ShugartYY, Yoo HS, Yuan W, Zhao G, Zilfalil BA; Indian Genome Variation Consortium (2009) Mapping humangenetichistoryinAsia. Science 326: 1541-1545.


*124) Naka I, Patarapotikul J, Tokunaga K, Hananantachai H, Tsuchiya N, Ohashi J (2009) A replication studyoftheassociationbetween the IL12B promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population.MalariaJournal 8: 290.


*123) Naka I, Nishida N, Patarapotikul J, Nuchnoi P, Tokunaga K, Hananantachai H, Tsuchiya N, Ohashi J (2009)Identificationof a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.MalariaJournal 8:232.


122) Noranate N, Prugnolle F, Jouin H, Tall A, Marrama L, Sokhna C, Ekala MT, Guillotte M, Bischoff E, Bouchier C,Patarapotikul J, Ohashi J, Trape JF, Rogier C, Mercereau-Puijalon O (2009) Population diversity andantibodyselectivepressureto Plasmodium falciparum MSP1 block 2 locus in an African malaria-endemic setting. BMCMicrobiology 9:219.


121) Makino H, Shimizu I, Murao S, Kondo S, TabaraY, Fujiyama M, Fujii Y, Takada Y, Nakai K, Izumi K, Ohashi J,KawamuraR,Yamauchi J, Takata Y, Nishida W, Hashiramoto M, Onuma H, Osawa H (2009)  A pilot study suggests that the G/Ggenotypeofresistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fastingplasmaglucoseandinsulin resistance by pioglitazone in type 2 diabetes. Endocrine Journal 56: 1049-1058.


*120) Naka I, Patarapotikul J, Hananantachai H, Tokunaga K, Tsuchiya N, Ohashi J (2009) IFNGR1polymorphismsinThaimalaria patients. Infection, Genetics and Evolution 9: 1406-1409.


*119) Fujimoto A, Nishida N, Kimura R, Miyagawa T, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Tsunoda T, Tokunaga K, Ohashi J (2009) FGFR2 is associated with hairthicknessinAsianpopulations. Journal of Human Genetics 54: 461-465.


118) Ito I, Kawaguchi Y, Kawasaki A, Hasegawa M, Ohashi J, Hikami K, Kawamoto M, Fujimoto M, Takehara K, Sato S, Hara M,Tsuchiya N (2009) Association of a functional polymorphism in the IRF5 region with systemic sclerosis inaJapanesepopulation.Arthritis & Rheumatism 60: 1845-1850.


*117) Ohashi J (2009) A practical case-control association test for detecting a susceptibility allele at acopynumbervariationlocus. Journal of Human Genetics 54: 169-173.


116) Osawa H, Tabara Y, Kawamoto R, Ohashi J, Ochi M, Onuma H, Nishida W, Yamada K, Nakura J, Miki T, Makino H,KoharaK (2009) PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergisticallyassociatedwithplasmaresistin in the Japanese general population. Clinical Endocrinology 71: 341-345.


115) Nantakomol D, Imwong M, Soontarawirat I, Kotjanya D, Khakhai C, Ohashi J, Nuchnoi P (2009) Theabsolutecountingofred cell-derived microparticles with red cell bead by flow rate based assay. Cytometry Part B:ClinicalCytometry76B: 191-198.


114) Ito I, Kawasaki A, Ohashi J, Hayashi T, Matsumoto I, Ito S, Tsutsumi A, Hom G, Graham RR, Takasaki Y, Hashimoto H,Behrens TW, Sumida T, Tsuchiya N (2009) Replication of the Association between C8orf13-BLK RegionandSystemicLupusErythematosus in a Japanese Population. Arthritis & Rheumatism 60: 553-558.


113) Mahasirimongkol S, Yanai H, Nishida N, Ridruechai C, Matsushita I, Ohashi J, Summanapan S, Yamada N, Moolphate S,Chuchotaworn C, Chaiprasert A, Manosuthi W, Kantipong P, Kanitwittaya S, Sura T, Khusmith S, Tokunaga K,SawanpanyalertP, Keicho N (2009) Genome-wide SNP-based linkage analysis of tuberculosis in Thais. Genes andImmunity10:77-83.



2008



112) Kawasaki A, Ito I, Hikami K, Ohashi J, Hayashi T, Goto D, Matsumoto I, Ito S, Tsutsumi A, Koga M, Arinami T,GrahamRR,Hom G, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya N (2008) Role of STAT4 polymorphismsinsystemiclupuserythematosus in a Japanese population: a case-control association study of STAT1-STAT4 region.ArthritisResearch &Therapy 10: R113.


111) Miyagawa T, Kawashima M, Nishida N, Ohashi J, Kimura R, Fujimoto A, Shimada M, Morishita S, Shigeta T, Lin L,HongSC,Faraco J, Shin YK, Jeong JH, Okazaki Y, Tsuji S, Honda M, Honda Y, Mignot E, Tokunaga K (2008) VariantbetweenCPT1BandCHKB associated with susceptibility to narcolepsy. Nature Genetics 40: 1324-1328.


*110) Teeranaipong P, Ohashi J, Patarapotikul J, Kimura R, Nuchnoi P, Hananantachai H, Naka I, Putaporntip C,JongwutiwesS, Tokunaga K (2008) A Functional SNP in the CR1 Promoter Region Contributes to ProtectionagainstCerebralMalaria. TheJournal of Infectious Diseases 198: 1880-1891.


*109) Fujimoto A, Ohashi J, Nishida N, Miyagawa T, Morishita Y, Tsunoda T, Kimura R, Tokunaga K (2008)Areplicationstudyconfirmed the EDAR gene to be a major contributor to population differentiation regarding head hairthicknessin Asia.HumanGenetics 124: 179-185.


108) Miyagawa T, Nishida N, Ohashi J, Kimura R, Fujimoto A, Kawashima M, Koike A, Sasaki T, Tanii H, Otowa T, Momose Y,Nakahara Y, Gotoh J, Okazaki Y, Tsuji S, Tokunaga K (2008) Appropriate data cleaning methods for genome-wideassociationstudy. Journal of Human Genetics 53: 886-893.


107) Shiota S, Tochigi M, Shimada H, Ohashi J, Kasai K, Kato N, Tokunaga K, Sasaki T(2008)Associationandinteractionanalyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population. Journal of HumanGenetics 53:929-935.


106) Kurashina K, Yamashita Y, Ueno T, Koinuma K, Ohashi J, Horie H, Miyakura Y, Hamada T, Haruta H, Hatanaka H, SodaM,Choi YL, Takada S, Yasuda Y, Nagai H, Mano H (2008) Chromosome copy number analysis in screening for prognosis-relatedgenomic regions in colorectal carcinoma. Cancer Science 99: 1835-1840.


105) Kimura R, Ohashi J, Matsumura Y, Nakazawa M, Inaoka T, Ohtsuka R, Osawa M, Tokunaga K (2008)GeneFlowandNatural Selection in Oceanic Human Populations, Inferred from Genome-wide SNP Typing. MolecularBiologyandEvolution 25:1750-1761.


*104) Nuchnoi P, Ohashi J, Naka I, Nacapunchai D, Tokunaga K, Nishida N, Patarapotikul J (2008)LinkageDisequilibriumStructure of the 5q31-33 Region in a Thai Population. Journal of Human Genetics 53: 850-856.


*103) Naka I, Ohashi J, Nuchnoi P, Hananantachai H, Looareesuwan S, Tokunaga K ,Patarapotikul J (2008)Lackofassociationof the HbE variant with protection from cerebral malaria in Thailand. Biochemical Genetics 46: 708-711.


102) Hirayasu K, Ohashi J, Tanaka H, Kashiwase K, Ogawa A, Takanashi M, Satake M, Jia GJ, Chimge NO, Sideltseva EW,Tokunaga K, Yabe T (2008) Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLAclassIinNortheast Asians. American Journal of Human Genetics 82: 1075-1083.


*101) Nuchnoi P, Ohashi J, Kimura R, Hananantachai H, Naka I, Krudsood S, Looareesuwan S, Tokunaga K, Patarapotikul J(2008) Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand.Annals of Human Genetics72: 327-336.


100) Fujimoto A, Kimura R, Ohashi J, Omi K, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W,Ishida T, Morishita Y, Furusawa T, Nakazawa M, Ohtsuka R, Tokunaga K (2008) A scan for geneticdeterminantsofhumanhairmorphology: EDAR is associated with Asian hair thickness. Human Molecular Genetics 17:835-843.


99) Murao S, Kondo S, Ohashi J, Fujii Y, Shimizu I, Fujiyama M, Ohno K, Takada Y, Nakai K, Yamane Y, Osawa H, Makino H(2008) Anti-thyroid peroxidase antibody, IA-2 antibody, and fasting C-peptide levels predict beta cell failureinpatientswithlatent autoimmune diabetes in adults (LADA) -a five year follow-up of the Ehime study-. DiabetesResearchandClinicalPractice 80: 114-121.


98) Kato C, Tochigi M, Ohashi J, Koishi S, Kawakubo Y, Yamamoto K, Matsumoto H, Hashimoto O, Kim S-Y, Watanabe K,Kano Y, Nanba E, Kato N, Sasaki T (2008) Association study of the 15q11-q13 maternal expression domaininJapaneseautisticpatients. American Journal of Medical Genetics Part B (NeuropsychiatricGenetics) 147B:1008-1012.


97) Osawa H, Yamada K, Tabara Y,Ochi M, Onuma H, Nishida W, Shimizu I, Kawamoto R, Fujii Y, Miki T, Ohashi J, Makino H(2008) The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8)doesnotaffect type 2 diabetes susceptibility despite the specific binding of AP2a. Clinical Endocrinology 69: 36-44.


96) Osawa H, Ochi M, Tabara Y, Kato K, Yamauchi J, Takata Y, Nishida W, Onuma H, Shimizu I, Fujii Y, Miki T,OhashiJMakinoH(2008) Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type2 diabetes.ClinicalEndocrinology 69: 74-80.


95) Kato K, Osawa H, Ochi M, Kusunoki Y, Ebisui O, Ohno K, Ohashi J, Shimizu I, Fujii Y, Tanimoto M, Makino H (2008)Serumtotal and high molecular weight adiponectin is correlated with the severity of diabetic retinopathy and nephropathy.Clinical Endocrinology 68: 442-449.


94) Osawa H, Tabara Y, Kawano R, Ohashi J, Ochi M, Onuma H, Nishida W, Yamada K, Nakura J, Kohara K, Miki T, Makino H(2008) Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL,and high sensitivity CRP in the Japanese general population. Diabetes Care 30: 1501-1506.


93) Tochigi M, Kato C, Ohashi J, Koishi S, Kawakubo Y, Yamamoto K, Matsumoto H, Hashimoto O, Kim S-Y, Watanabe K ,KanoY, Nanba E, Kato N, Sasaki T (2008) No association between the ryanodine receptor 3 gene and autisminaJapanesepopulation. Psychiatry and Clinical Neurosciencse 62: 341-344.


92) Kawasaki A, Kyogoku C, Ohashi J, Miyashita R, Hikami K, Kusaoi M, Tokunaga K, Takasaki Y, Hashimoto H, Behrens TW,Tsuchiya N (2008) Association of interferon regulatory factor 5 (IRF5) polymorphisms with systemiclupuserythematosusinJapanese: Support for a crucial role of intron 1 polymorphisms. Arthritis & Rheumatism58: 826-834.


91) Shi L, Ogata S, Yu JK, Ohashi J, Yu L, Shi L, Sun H, Lin K, Huang XQ, Matsushita M, Horai S, Muramatsu M, Chu JY,Tokunaga K (2008) Distribution of HLA alleles and haplotypes in Jinuo and Wa populations in Southwest China.HumanImmunology 69: 58-65.


90) Yamauchi J, Osawa H, Takasuka T, Ochi M, Murakami A, Nishida W, Onuma H, Takata Y, Tabara Y, Miki T, Ohashi J,MakinoH (2008) Serum resistin is reduced by glucose and meal loading in healthy human subjects. Metabolism 57: 149-156.


89) Hoa BK, Hang NTL, Kashiwase K, Ohashi J, Lien LT, Horie T, Shojima J, Hijikata M, Sakurada S, Satake M, Tokunaga K,Sasazuki T, Keicho N (2008) HLA-A, B, C, DRB1 and DQB1 alleles and haplotypes in the Kinh population in Vietnam.TissueAntigens 71: 127-134.



2007



88) Ohashi J, Naka I, Kimura R, Natsuhara K, Yamauchi T, Furusawa T, Nakazawa N, Ataka Y, Patarapotikul J, Nuchnoi P,Tokunaga K, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R (2007) FTO polymorphisms in Oceanic populations.JournalofHumanGenetics 52: 1031-1035.


87) Suga T, Ishikawa A, Kohda M, Otsuka Y, Yamada S, Yamamoto N, Shibamoto Y, Ogawa Y, Nomura K, Sho K, Omura M,Sekiguchi K, Kikuchi Y, Michikawa Y, Noda S, Sagara M, Ohashi J, Yoshinaga S, Mizoe J, Tsujii H, Iwakawa M, Imai T (2007)Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients.International Journal of Radiation Oncology Biology Physics 69: 685-693.


86) Ochi M, Osawa H, Hirota Y, Hara K, Tabara Y, Tokuyama Y, Shimizu I, Kanatsuka A, Fujii Y, Ohashi J, Miki T, Nakamura N,Kadowaki T, Itakura M, Kasuga M, Makino H (2007) Frequency of the G/G genotype of resistinsinglenucleotidepolymorphismat -420 appears to be increased in younger onset type 2 diabetes. Diabetes 56: 2834-2838.


*85) Naka I, Ohashi J, Patarapotikul J, Hananantachai H, Wilairatana P, Looareesuwan S, Tokunaga K (2007)Thegenotypesof GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria.JournalofHumanGenetics52: 476-479.


84) Kimura R, Fujimoto A, Tokunaga K, Ohashi J(2007) A practical genome scan for population-specificstrongselectivesweepsthat have reached fixation. PLoS One 2: e286.


83) Osawa H, Ochi M, Kato K, Yamauchi J, Nishida W, Takata Y, Kawamura R, Onuma H, Takasuka T, Shimizu I, Fujii Y,OhashiJ, Makino H (2007) Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.Biochemicaland Biophysical Research Communications 355: 342-346.


*82) Hananantachai H, Patarapotikul J, Ohashi J, Naka I, Krudsood S, Looareesuwan S, Tokunaga K (2007)Significantassociation between TNF-a (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand.Tissue Antigens 69: 277-280.


81) Kawasaki A, Tsuchiya N, Ohashi J, Murakami Y, Fukazawa T, Kusaoi M, Morimoto S, Matsuta K, Hashimoto H, Takasaki Y,Tokunaga K (2007) Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosusinJapanese.Rheumatology 46: 776-782.


80) Tamura Y, Kunugi H, Ohashi J, Hohjoh H (2007) Epigenetic aberration of the human REELIN gene in psychiatric disorders.Molecular Psychiatry 12: 593-600.


79) Ogata S, Shi L, Matsushita M, Liang YU, Huang XQ, Lei SHI, Sun H, Ohashi J, Muramatsu M, Tokunaga K, Chu JY (2007)Polymorphisms of HLA genes in Maonan people in China. Tissue Antigens 69:154-160.


78) Choi YL, Tsukasaki K, O'neill MC, Yamada Y, Onimaru Y, Matsumoto K, Ohashi J, Yamashita Y, Tsutsumi S, Kaneda R,Takada S, Aburatani H, Kamihira S, Nakamura T, Tomonaga M, Mano H (2007) A genomic analysis of adult T-cell leukemia.Oncogene 26: 1245-1255.


77) Tochigi M, Zhang X, Ohashi J, Hibino H, Otowa T, Rogers M, Kato T, Okazaki Y, Kato N, Tokunaga K, Sasaki T (2007)Association study between the TNXB locus and schizophrenia in a Japanese population. AmericanJournalofMedicalGeneticsPart B (Neuropsychiatric Genetics) 144: 305-309.



2006



*76) Ohashi J, Naka I, Toyoda A, Takasu M, Tokunaga K, Ishida T, Sakaki Y, Hohjoh H (2006) Estimation of the species-specific mutation rates of the DRB1 locus in human and chimpanzee. Tissue Antigens 68: 427-431.


75) Dechkum N, Hananantachai H, Patarapotikul J, Ohashi J, Krudsood S, Looareesuwan S, Tokunaga K (2006)MonocyteChemoattractant Protein 1 (MCP-1) Gene Polymorphism Is Not Associated with Severeand CerebralMalariainThailand.Japanese Journal of Infectious Diseases 59: 239-244.


74) Tochigi M, Suga M, Ohashi J, Otowa T, Yamasue H, Kasai K, Kato T, Okazaki Y, Kato N, Sasaki T (2006)Noassociationbetween the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population.SchizophreniaResearch 88:260-264.


73) Tochigi M, Zhang X, Ohashi J, Hibino H, Otowa T, Rogers M, Kato T, Okazaki Y, Kato N, Tokunaga K, Sasaki T (2006)Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population. Neuroscience Research 56:154-158.


72) Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Tobe K, Nagai R, Kadowaki T(2006)Hepatocyte Nuclear Factor-4a P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population.Diabetes 55: 1260-1264.


71) Jalloh A, van Thien H, Ferreira MU, Ohashi J, Matsuoka H, Kanbe T, Kikuchi A, Kawamoto F (2006)SequenceVariationintheT-Cell Epitopes of the Plasmodium falciparum Circumsporozoite Protein among Field Isolates IsTemporallyStable: a 5-Year Longitudinal Study in Southern Vietnam. Journal of Clinical Microbiology 44: 1229-1235.


70) Horikoshi M, Hara K, Ohashi J, Miyake K, Tokunaga K, Ito C, Kasuga M, Nagai R, Kadowaki T (2006) APolymorphismintheAMPKa2 Subunit Gene Is Associated With Insulin Resistance and Type2 Diabetes in the JapanesePopulation. Diabetes55:919-923.


*69) Ohashi J, Naka I, Kimura R, Tokunaga K, Nakazawa M, Ataka Y, Ohtsuka R, Inaoka T, Matsumura Y (2006) HLA-DRB1polymorphism on Ha’ano Island of the Kingdom of Tonga. Anthropological Science 114: 193-198.


68) Hirayasu K, Ohashi J, Kashiwase K, Takanashi M, Satake M, Tokunaga K, Yabe T. (2006) Long-termpersistenceofbothfunctional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3)locussuggestsbalancingselection. Human Genetics 119: 436-443.


*67) Ohashi J, Naka I, Kimura R, Tokunaga K, Yamauchi T, Natsuhara K, Furusawa T, Yamamoto R, Nakazawa M, Ishida T,Ohtsuka R. (2006) Polymorphisms in the ABO blood group gene in three populations in New Georgia Islands,SolomonIslands.Journal of Human Genetics 51: 407-411.


*66) Ohashi J, Naka I, Tokunaga K, Inaoka T, Ataka Y, Nakazawa M, Matsumura Y, Ohtsuka R. (2006)MitochondrialDNAvariation suggests extensive gene flow from Polynesian ancestors to indigenous Melanesians inthenorthwesternBismarckarchipelago. American Journal of Physical Anthropology 130:551-556.


65) Shi L, Xu SB, Ohashi J, Sun H, Yu JK, Huang XQ, Tao YF, Yu L, Horai S, Chu JY, Tokunaga K. (2006) HLA-A, HLA-B,andHLA-DRB1 alleles and haplotypes in Naxi and Han populations in southwestern China (Yunnan province).TissueAntigens67:38-44.



2005



*64) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Tangpukdee N, Looareesuwan S, Tokunaga K (2005)Afunctionalpolymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.MalariaJournal 4:38.


63) Osawa H, Onuma H, Ochi M, Murakami A, Yamauchi J, Takasuka T, Tanabe F, Shimizu I, Kato K, Nishida W, Yamada K,Tabara Y, Yasukawa M, Fujii Y, Ohashi J, Miki T, Makino H (2005) Resistin SNP-420 determines its monocytemRNAandserumlevels inducing type 2 diabetes. Biochemical Biophysical and Research Communications 335: 596-602.


62) Nam MH, Hijikata M, Tuan le A, Lien LT, Shojima J, Horie T, Nakata K, Matsushita I, Ohashi J, Tokunaga K, Keicho N.(2005) Variations of the CFTR gene in the Hanoi-Vietnamese. American Journal of Medical Genetics A 136: 249-253.


61) Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T.(2005) Absence of an association between the polymorphisms in the genes encoding adiponectin receptors andtype2diabetes.Diabetologia. 48: 1307-1314.


60) Zhang X, Tochigi M, Ohashi J, Maeda K, Kato T, Okazaki Y, Kato N, Tokunaga K, Sawa A, Sasaki T. (2005)Associationstudy of the DISC1/TRAX locus with schizophrenia in a Japanese population. Schizophrenia Research 79: 175-180.


59) Tanaka G, Matsushita I, Ohashi J, Tsuchiya N, Ikushima S, Oritsu M, Hijikata M, Nagata T, Yamamoto K, Tokunaga K,Keicho N (2005) Evaluation of microsatellite markers in association studies: a search for an immune-relatedsusceptibilitygenein sarcoidosis. Immunogenetics 56: 861-870.


*58) Ohashi J, Clark AG (2005) Application of the stepwise focusing method to optimization of the cost-effectivenessofgenome-wide association study with limited research budget for genotyping and phenotyping. Annals of Human Genetics69:323-328


*57) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan S, Clark AG, Tokunaga K (2005)Strong linkage disequilibrium of a HbE variant with the (AT)9(T)5 repeat in the BP1 binding site upstream of the b-globingenein Thai population. Journal of Human Genetics 50: 7-11.


*56) Hananantachai H, Patarapotikul J, Ohashi J, Naka I, Looareesuwan S, Tokunaga K (2005) Polymorphisms of HLA-BandHLA-DRB1 genes in Thai malaria patients. Japanese Journal of Infectious Diseases 58: 25-28.



2004



55) Akesaka T, Lee SG, Ohashi J, Bannai M, Tsuchiya N, Yoon Y, Tokunaga K, Song K (2004) Comparativestudyofthehaplotype structure and linkage disequilibrium of chromosome 1p36.2 region in the Korean and Japanesepopulations.  Journal of HumanGenetics 49: 603-609.


54) Hitomi Y, Tsuchiya N, Kawasaki A, Kyogoku C, Ohashi J, Suzuki T, Fukazawa T, Bejrachandra S, Siriboonrit U,Chandanayingyong D, Suthipinittharm P, Tsao BP, Hashimoto H, Honda ZI, Tokunaga K (2004)CD72polymorphismsassociated with alternative splicing modify susceptibility to human systemiclupuserythematosusthroughepistatic interactionwith FCGR2B. Human Molecular Genetics13:2907-2917.


53) Itoyama S, Keicho N, Quy T, Phi NC, Long HT, Ha LD, Ban VV, Ohashi J, Hijikata M, Matsushita I, Kawana A, Yanai H,Kirikae T, Kuratsuji T, Sasazuki T (2004) ACE1 Polymorphism and Progression of SARS. BiochemicalBiophysicalandResearchCommunications 323: 1124-1129.


52) Osawa H, Yamada K, Onuma H, Murakami A, Ochi M,Hiroko Kawata, Nishimiya T, Niiya T, Shimizu I, Nishida W,Hashiramoto M, Kanatsuka A, Fujii Y, Ohashi J, Makino M (2004) The G/G Genotype of a Resistin Single-NucleotidePolymorphism at -420 Increases Type 2 Diabetes Mellitus Susceptibility by Inducing PromoterActivitythroughSpecificBinding of Sp1/3. American Journal of Human Genetics 75:678-686.


51) Murao S, Makino H, Kaino Y, Konoue E, Ohashi J, Kida K, Fujii Y, Shimizu I, Kawasaki E, Fujiyama M, Kondo S, Tanaka K,Tarumi Y, Seto I, Kato K, Ohno K, Ebisui O, Takada Y, Tanabe K, Takemoto K, Onuma H, Nishimiya T, Osawa H (2004)Differences in the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Adult-Onset and Childhood-OnsetType1Diabetes in Japanese Patients. Diabetes 53: 2684-2690.


50) Kamio K, Matsushita I, Tanaka G, Ohashi J, Hijikata M, Nakata K, Tokunaga K, Azuma A, Kudoh S, Keicho N (2004)Directdetermination of MUC5B promoter haplotypes based on the method of single-strand conformationpolymorphismandtheirstatistical estimation. Genomics 84: 613-622.


49) Sato-Takeda M, Ihn H, Ohashi J, Tsuchiya N, Ishikawa Y, Satake M, Arita H, Tamaki K, Hanaoka K, Tokunaga K, Yabe T(2004) The human histocompatibility leukocyte antigen (HLA) haplotype is associated with the onsetofpostherpeticneuralgiaafter herpes zoster. Pain 110: 329-336.


48) Araki J, Ohashi J, Muramatsu M (2004) Application of discordant sib-pair linkage analysisformappingminorhistocompatibility antigen loci in a novel graft-versus-host-disease model. Tissue Antigens64: 243-250.


47) Ohki-Kaneda R, Ohashi J, Yamamoto K, Ueno S, Ota J, Choi YL, Koinuma K, Yamashita Y, Misawa Y, Fuse K, Ikeda U,Shimada K, Mano H (2004) Cardiac function-related gene expression profiles in human atrial myocytes.BiochemicalBiophysicalResearch Communications 320: 1328-1336.


*46) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan S, Clark AG, Tokunaga K (2004)Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. AmericanJournalofHumanGenetics 74: 1198-1208.


45) Tochigi M, Zhang X, Umekage T, Ohashi J, Kato C, Marui T, Otowa T, Hibino H, Otani T, Kohda K, Liu S, Kato N,TokunagaK, Sasaki T (2004) Association of six polymorphisms of the NOTCH4 gene with schizophreniaintheJapanesepopulation. American Journal of Medical Genetics 128B: 37-40.


44) Chu ZT, Tsuchiya N, Kyogoku C, Ohashi J, Qian YP, Xu SB, Mao CZ, Chu JY, Tokunaga K (2004) AssociationofFcgreceptorIIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibilitygeneinthe Asianpopulations. Tissue Antigens 63: 21-27.


43) Choi YL, Makishima H, Ohashi J, Yamashita Y, Ohmine K, Ohki R, Wada T, Koinuma K, Ota J, Isobe Y, Ishida F, Ymauchi K,Oshimi K, Mano H (2004) DNA microarray analysis of natural killer cell-type lymphoproliferative diseaseofgranularlymphocyteswith purified CD3-CD56+ fractions. Leukemia 18: 556-565.


*42) Ohashi J, Naka I, Ohtsuka R, Inaoka T, Ataka Y, Nakazawa M, Tokunaga K, Matsumura Y (2004)Molecularpolymorphismof ABO blood group gene in Austronesian and Non-Austronesian populations in Oceania.TissueAntigens 63:355-361.


2003



41) Ochi M, Osawa H, Onuma H, Murakami A, Nishimiya T, Shimada F, Kato K, Shimizu I, Shishino K, Murase M, Fujii Y,OhashiJ, Makino H (2003) The absence of evidence for major effects of the frequent SNP +299G>A in theresistingeneonsusceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes. DiabetesResearchandClinicalPractice61: 191-198.


*40) Ohashi J, Maruya E, Tokunaga K, Saji H (2003)Power of association test fordetectionminorhistocompatibilitygenecausing graft-versus-host disease following bone marrow transplantation. Journal ofHumanGenetics48: 502-507.


*39) Ohashi J, Tokunaga K (2003) The power of genome-wide linkage disequilibrium (LD) testing usingmicrosatellitemarkers.Journal of Human Genetics 48: 487-491.


38) Hohjoh H, Ohashi J, Takasu M, Nishioka T, Ishida T, Tokunaga K (2003) Recent divergence of the HLA-DRB1*04alleliclineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species. Immunogenetics 54:856-861.


37) Tarasenko O, Ohashi J, Ataka Y, Inaoka T, Ohtsuka R, Tokunaga K (2003) HLA-DRB1 polymorphism ofBalopaislandersinPapua New Guinea. Anthropological Science 111: 157-164.


36) Ataka Y, Ohtsuka R, Inaoka T, Kawabata M, Ohashi J, Matsushita M, Tokunaga K, Kano S, Suzuki M (2003)Variationinmalaria endemicity in relation to microenvironmental conditions in the Admiralty Islands, Papua New Guinea. Asia-PacificJournal of Public Health 13: 85-90.


35) Osawa H, Niiya T, Onuma H, Murakami A, Ochi M, Nishimiya T, Ogura T, Kato K, Shimizu I, Fujii Y, Ohashi J, Yamada K,Liang SJ, Manganiello VC, Fujita-Yamaguchi Y, Makino H (2003) Systematic search for single nucleotide polymorphisms (SNPs)in the 5’ flanking region of the human phosphodiesterase 3B gene: absence of evidence for majoreffectsofidentifiedpolymorphisms on susceptibility to Japanese type 2 diabetes. Molecular Genetics and Metabolism 79:43-51.


*34) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2003) Asinglenucleotidesubstitutionfrom C to T at position -1055 in the IL-13 promoter is associated with protection from severemalaria inThailand.Genes andImmunity 4: 528-531.


*33) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K (2003)CD36polymorphismisassociated with protection from cerebral malaria. American Journal of Human Genetics 72: 364-374.


32) Osawa H, Onuma H, Murakami A, Ochi M, Mishimiya T, Kato K, Shimizu I, Fujii Y, Ohashi J, Makino H (2003)Systematicsearch for single nucleotide polymorphisms (SNPs) in the FOXC2 gene:The Absence of evidence fortheassociationof threefrequent SNPs and four common haplotypes with Japanese type 2 diabetes. Diabetes 52:562-567.



2002



*31) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K (2002)AbsenceofAssociationbetween the Fcg receptor IIIA-176F/V Polymorphism and the Severity of Malaria in Thai. JapaneseJournalofInfectiousDiseases 55: 167-169.


*30) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K (2002) Fcg receptorIIAandIIIBpolymorphisms are associated with susceptibility to cerebral malaria. Parasitology International 51: 361-366.


29) Tochigi M, Ohashi J, Umekage T, Koda K, Hibino H, Otowa T, Marui T, Masui K, Sugahara Y, Kanamori R, Juji T, Kato N,Tokunaga K, Sasaki T (2002) HLA-A specificities and its relation with season of birth in Japanese patients with schizophrenia.Neuroscience Letters 329: 201-204.


*28) Ohashi J, Tokunaga K (2002) The expected power of genome-wide linkage disequilibrium testingusingsinglenucleotidepolymorphism markers for detecting a low-frequency disease variant. Annals of Human Genetics 66: 297-306.


*27) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2002) Significantassociationoflongerforms of CCTTT microsatellite repeat in inducible nitric oxide synthase (iNOS) promoter with severemalariainThailand.  TheJournal of Infectious Diseases 186: 578-581.


26) Sato M, Ohashi J, Tsuchiya N, Kashiwase K, Ishikawa Y, Arita H, HanaokaK, Tokunaga K, Yabe T (2002) Association ofHLA-A*3303-B*4403-DRB1*1302 haplotype, but not of TNFa promoter and NKp30 polymorphism, with postherpeticneuralgia(PHN) in the Japanese population. Genes and Immunity 3: 477-481.


25) Osawa H, Onuma H, Murakami A, Ochi M, Nishimiya T, Kato K, Shimizu I, Fujii Y, Ohashi J, Makino H (2002)Systematicsearch for single nucleotide polymorphisms in the resistin gene. The absence of evidence for the associationofthreeidentifiedsingle nucleotide polymorphisms with Japansese type 2 diabetes. Diabetes 51: 863-866.



2001



24) Osawa H, Ochi M, Nishimiya T, Onuma H, Nakamaru K, Murakami A, Kato K, Shimizu I, Fujii Y, Ohashi J, Makino H (2001)Asystematic search for single nucleotide polymorphisms (SNPs) in the insulin receptor gene: Association ofansSNPwithhyperlipidemia in Japanese type 2 diabetic subjects. Clinical Genetics 60: 479-481.


*23) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2001)Absenceofassociationbetweenthe allele coding methionine at position 29 in the N-terminal domain of ICAM-1 (ICAM-1Kilifi)and severemalaria inthenorthwest of Thailand. Japanese Journal of Infectious Diseases 54: 114-116.


22) Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, Tokunaga K, Yabe T (2001) Identificationofnovelsinglenucleotide substitutions in the NKp30 gene expressed in human natural killer cells. Tissue Antigens 58: 255-258.


21) Osawa H, Onuma H, Murakami A, Ochi M, Nishimiya T, Kato K, Shimizu I, Fujii Y, Ohashi J, Makino H (2001)Systematicsearch for single nucleotide polymorphisms in the Insulin gene: evidence for a high frequency of -23T>AinJapanesesubjects. Biochemical and Biophysical Research Communications 286:451-455.


*20) Ohashi J, Tokunaga K (2001) Power of genomewide association studies of complex disease genes:Statisticallimitationofindirect approaches using SNP markers. Journal of Human Genetics 46: 478-482.


*19) Ohashi J, Yamamoto S, Tsuchiya N, Hatta Y, Komata T, Matsushita M, Tokunaga K (2001) Comparisonofstatisticalpowerbetween 2 × 2 allele frequency and allele positivity tables in case-control studies of complex disease genes.Annals ofHumanGenetics 65: 197-206.


*18) Hananantachai H, Patarapotikul J, Looareesuwan S, Ohashi J, Naka I, Tokunaga K (2001) Lack of association of -308A/GTNFA promoter and 196R/M TNFR2 polymorphisms with disease severity in Thai adult malaria patients.AmericanJournalofMedical Genetics 102: 391-392.


17) Lin M, Chu CC, Chang SL, Lee JH, Loo HH, Akaza T, Juji T, Ohashi J, Tokunaga K (2001) The origin of Minnan and Hakka,the so-called “Taiwanese”, inferred by HLA study. Tissue Antigens 57: 192-199.


*16) Tarasenko O, Ohashi J, Kitaev M, Razorilova S, Ardiyants A, Kutukeev T, Alisherov A, Toktorgazieva K, Tokunaga K(2001) HLA-DRB1 gene polymorphism in the Kyrgyz population. MHC 8:40-46.



2000



*15) Tarasenko O, Ohashi J, Kitaev M, Alisherov A, Tyurebaeva B, Kutukeev T, Tokunaga K (2000) Polymorphisms of HLA-Aand -B genes in the Kyrgyz population. Anthropological Science 108:293-303.


*14) Ohashi J, Tokunaga K (2000) Computer simulation analysis suggests weak balancing selection operative at theMICAlocu.Hereditas 131:25-28.


13) Tsuchiya N, Komata T, Matsushita M, Ohashi J, Tokunaga K (2000) New single nucleotide polymorphismsinthecodingregion of human TNFR2. Genes & Immunity 1:501-503.


12) Wu MS, Tani K, Sugiyama H, Hibino H, Izawa K, Tanabe T, Nakazaki Y, Ohashi J, Hohjoh H, Iseki T, Tojo A, Nakamura Y,Tanioka Y, Tokunaga K, Asano S (2000) MHC (Major Histocompatibility Complex) -DRB genes andpolymorphismsinCommonMarmoset. Journal of Molecular Evolution 51:214-222.


*11) Ohashi J, Tokunaga K (2000) Sojourn times and substitution rate at overdominant and linked neutral loci. Genetics 155:921-927.


*10) Ohashi J, Yoshida M, Ohtsuka R, Nakazawa M, Juji T, Tokunaga K (2000) Analysis of HLA-DRB1polymorphisminGidraliving in South New Guinea. Human Biology 72:337-347.


9) Shibue T, Tsuchiya N, Komata T, Matsushita M, Shiota M, Ohashi J, Wakui M, Matsuta K, Tokunaga K (2000)Tumornecrosisfactor a 5’-flanking region, TNF receptor II and HLA-DRB1 polymorphisms in Japanesepatientswithrheumatoidarthritis.Arthritis & Rheumatism 43:753-757.


8) Keicho N, Ohashi J, Tamiya G, Nakata K, Taguchi Y, Azuma A, Ohishi N, Emi M, Park MH, Inoko H, Tokunaga K, Kudoh S(2000) Fine localization of a major disease-susceptibility locus for diffuse panbronchiolitis. AmericanJournalofHumanGenetics66:501-507.


7) Bannai M, Ohashi J, Harihara S, Mitomi Y, Takahashi Y, Juji T, Omoto K, Tokunaga K (2000)Analysis ofHLAgenesandhaplotypes in Ainu (from Hokkaido, northern Japan) supports the premise that they decent fromUpperPaleolithicpopulationsof East Asia.  Tissue Antigens 55:128-139.


6) Lin M, Chu CC, Lee HL, Chang SL, Ohashi J, Tokunaga K, Akaza T, Juji T (2000) Heterogeneity of Taiwan’sindigenouspopulation: possible relation to prehistoric Mongoloid dispersals. Tissue Antigens 55: 1-9.



1999



5) Matsushita M, Tsuchiya N, Nakayama T, Ohashi J, Shibue T, Shiota M, Oka T, Yamane A, Tokunaga K (1999)Alleletypingofhuman TNFA 5’-flanking region using PCR-PHFA (preferential homoduplex formation assay): linkagedisequilibriumwithHLAclass I and class II genes in Japanese. Tissue Antigens 54: 478-484.


4) Hatta Y, Tsuchiya N, Ohashi J, Matsushita M, Fujiwara K, Hagiwara K, Juji T, Tokunaga K (1999) AssociationofFcgreceptorIIIB, but not of Fcg receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus in Japanese.GenesandImmunity 1:53-60.


3) Hohjoh H, Nakayama T, Ohashi J, Miyagawa T, Tanaka H, Akaza T, Honda Y, Juji T, and Tokunaga K (1999)Significantassociation of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-a)genepromoterwithhuman narcolepsy. Tissue Antigens 54: 138-145.


*2) Ohashi J, Tokunaga K (1999) Selecting contingency table in population-based association study:allelefrequencyorpositivity? Journal of Human Genetics 44: 246-248.


*1) Hatta Y, Ohashi J, Imanishi T, Kamiyama H, Iha M, Shimabukuro T, Ogawa A, Tanaka H, Akaza T, Gojobori T, Juji T,Tokunaga K (1999) HLA genes and haplotypes in Ryukyuan suggest recent gene flow to the Okinawa islands.HumanBiology71: 353-365.



邦文原著論文


*1) 大橋 順 2012 Extended Haplotype Homozygosity (EHH)を用いる正の自然選択検出法の検出力比較. 統計数理 60: 317-325.



総説・本


大橋 順 2014 ゲノム人類学への招待―アジア集団の遺伝的近縁関係に関する研究を例に. 医学のあゆみ. Vol 248, No 10, pp817-819.


大橋 順、川嶋 実苗 2013 HLA遺伝子の進化と自然選択―HLA-DPB1*04:01アリルに最近作用した正の自然選択―.  生物の科学遺伝. Vol.67. No.3, pp346-352.


大橋 順 2011 疾患とコピー数多型アリルとのケース-コントロール関連検定. 生体の科学. Vol 62, No 6, pp535-540.


大橋 順 2010 アジア集団の遺伝的多様性解析からわかること. 医学のあゆみ. Vol 235, No 2, pp191-192.


大橋 順 2009 第3章2 遺伝子疾患関連研究で必要とされるサンプルサイズ. 実験医学(増刊). Vol 27, No 12, pp670-676.


Kimura R, Ohashi J (2008) Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection.HandbookofHuman Molecular Evolution, 2 Volume Set. Cooper DN, Kehrer-Sawatzki eds. Wiley. 2008.


大橋 順 2005 bグロビン遺伝子に作用する正の自然淘汰. 医学のあゆみ. Vol 214, No 7-8, pp670-676.


大橋 順 2005 疾患感受性遺伝子の探査法―理論と戦略. 腎と透析. Vol 58, No 3, pp262-269.


田中紀子、大橋 順 2003 Genomic Control. 分子精神医学. Vol 3, No 2, pp62(150)-62(152).


Tsuchiya N, Ohashi J, Tokunaga K (2002) Variations in immune response genesandtheirassociationswithmultifactorialimmunedisorders. Immunological reviews 190: .169-181.


大橋 順 2003 疾患感受性遺伝子探査の理論と戦略. Molecular Medicine. Vol 40, No 1, pp18-25.


大橋 順 2003 高血圧症の感受性遺伝子は見つかるか?―遺伝学的アプローチによる感受性変異の探索−.診断と治療.Vol 91, No 1,pp 133-143.


大橋 順 2002 多因子疾患における感受性多型の関連解析.腎と透析.Vol 53, No 3, pp 333-339.


大橋 順 2002 形質関連遺伝子探索の理論と手法.脳と精神の医学.Vol 13, No 3, pp 265-274.


大橋 順 2002関連分析法.医学のあゆみ.Vol 202, No 10, pp 754-758.


大橋 順、土屋尚之、徳永勝士 2002 HLA遺伝子と人類遺伝学.分子細胞治療.Vol 1, No 4, pp 428-433.


大橋 順、徳永勝士 2001多因子疾患の遺伝疫学的解析法. ゲノム医学. Vol 1, No 2, pp 51-58.


徳永勝士、大橋 順 2001疾患遺伝子の探索. わかる実験医学シリーズ ゲノム医科学がわかる. pp 48-55.


Tokunaga K, Ohashi J, Bannai M, Juji T (2001) Genetic Link between Asians and Native Americans:EvidencefromHLAgenesandhaplotypes. Human Immunology 62:1001-1008.


大橋 順 2001疾患感受性遺伝子探索を目的とするcase-control研究において必要なサンプル数. 分子精神医学.Vol.1. No.3: 87(303)-88(304).


Komatsu-Wakui M, Ohashi J, Tokunaga K, Ishikawa Y, Kashiwase K, Ando H, Shiina T, Geraghty DE, Inoko H, Juji T (2000)MIC-A polymorphism and a MIC-A-MIC-B null haplotype with〜100-kb deletion. Major Histocompatibility Complex. Kasahara M(ed.) Springer. pp 480-486.


大橋 順, 徳永勝士2000 HLAにみられる集団差の由来. Molecular Medicine. Vol.37. No.5: 548-555.


大橋 順, 徳永勝士 2000 遺伝子からみた現生人類の起源と進化―ヒトゲノムの多様性(2)―. 生物の科学 遺伝. Vol.54. No.4: 42-47.


大橋 順, 徳永勝士1999 HLAの多型: 命名法・起源・意義. Diabetes Frontier. Vol.10. No.3: 393-399.


大橋 順, 徳永勝士1998 HLA遺伝子から: 遺伝子から探る日本人の起源(1). 生物の科学 遺伝. Vol.52. No.10: 48-53.


大橋 順, 徳永勝士 1998 HLAからみた日本人の成り立ち. 病理と臨床. Vol.16. No.7: 851-857.



著書


大橋 順 2014 第3章3.7 バイオインフォマティクス. 毒性の科学. 熊谷嘉人,姫野誠一郎,渡辺知保編. 東京大学出版会. pp 103-106.


大橋 順, 徳永勝士 2007 第3章 統計遺伝学. 人類遺伝学ノート. 徳永勝士編. 南山堂. pp 41-62.


大橋 順 2007 第4章 集団遺伝学. 臨床ゲノム科学入門. 徳永勝士, 山崎力, 大木秀一編. 杏林図書. pp 54-71.


大橋 順 2007 第5章 関連解析. 臨床ゲノム科学入門. 徳永勝士, 山崎力, 大木秀一編. 杏林図書. pp 72-89.


大橋 順 2007 第6章 LDマッピング. 臨床ゲノム科学入門. 徳永勝士, 山崎力, 大木秀一編. 杏林図書. pp 90-108.


大橋 順 2001 case-control studyの理論. ポストゲノム時代の遺伝統計学. 鎌谷直之編. 羊土社. pp 219-230.