ヒトゲノム多様性研究室

 
 中 伊津美(Izumi Naka)

略歴

2014年10月 東京大学大学院理学系研究科生物科学専攻特任研究員
2014年  4月 筑波大学医学医療系研究員
2013年  4月 日本学術振興会特別研究員(PD(DC2からの変更))
2013年  3月 博士(医学)取得(筑波大学)
2012年  4月 日本学術振興会特別研究員(DC2)
2009年  4月 筑波大学大学院人間総合科学研究科生命システム医学専攻入学
2008年11月 筑波大学医学系支援室(〜2012年3月)
2000年  4月 東京大学大学院医学系研究科人類遺伝学分野技術補佐員(〜2008年10月)
  研究業績 


英文原著論文


2017


51) Naka I, Furusawa T, Kimura R, Natsuhara K, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, Inaoka T, Matsumura Y,Ohtsuka R, Ohashi J. A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanicpopulations. Journal of Human Genetics (in press)


50) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa M, Ishida T, Ohtsuka R, Ohashi J (2017)Polymorphisms Associated with a Tropical Climate and Root Crop Diet Induce Susceptibility to Metabolic and CardiovascularDiseases in Solomon Islands. PLoS ONE 12: e0172676.


49) Yasukochi Y, Naka I, Patarapotikul J, Hananantachai H, Ohashi J (2017) Evolution of Fseg/Cseg dimorphism in region IIIof Plasmodium falciparum eba-175 gene. Infection, Genetics and Evolution 49: 251-255.


2016


48) Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Wichukchinda N, Sawanpanyalert P, Patarapotikul P, Tsuchiya N,Ohashi J (2016) Association of BAK1 single nucleotide polymorphism with a risk for dengue hemorrhagic fever. BMC MedicalGenetics 17: 43


47) Ohashi J, Naka I, Hananantachai H, Patarapotikul J. Association of PECAM1/CD31 polymorphisms with cerebral malaria.International Journal of Molecular Epidemiology and Genetics 7: 87-94.


2015


46) Yasukochi Y, Naka I, Hananantachai H, Patarapotikul J, Ohashi J (2015) Genetic evidence for contribution of  human dispersal to the genetic diversity of EBA-175 in Plasmodium falciparum.  Malaria Journal 14: 293.


2014


45) Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Chanama S, Wichukchinda N, Sawanpanyalert P, Patarapotikul P,Tsuchiya N, Ohashi J (2014) A replication study confirms the association of GWAS-identified SNPs at MICB and PLCE1 in Thai  patients with dengue shock syndrome. BMC Medical Genetics 15: 58.


44) Naka I, Patarapotikul J, Hananantachai H, Imai H, Ohashi J(2014)Association of the endothelial protein C receptor(PROCR) rs867186-G allele with protection from severe malaria. Malaria Journal 13:105  doi:10.1186/1475-2875-13-105.


43) Naka I, Patarapotikul J, Hananantachai H, Ohashi J(2014)Lack of Association between BSG Polymorphisms andCerebral Malaria. Japanese Journal of Infectious Diseases 67(6):432-5.


42) Ohashi J, Suzuki Y, Naka I, Hananantachai H, Patarapotikul J(2014)Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum in Thailand. PLoS ONE 9: e90522.


41) Sa-Ngasang A, Ohashi J, Naka I, Anantapreecha S, Sawanpanyalert P, Patarapotikul J(2014)Association of IL1B -31C/Tand IL1RA variable number of an 86-bp tandem repeat with Dengue Shock Syndrome in Thailand. The Journal of InfectiousDiseases 210(1):138-145.


2013


40) Naka I, Ohashi J, Kimura R, Inaoka T, Matsumura Y (2013) Association of ADRB2 polymorphism with triglyceride levelsinTongans. Lipids in Health and Disease 12: 110.


39) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y,AtakaY,Ohtsuka R, Ohashi J (2013) Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations withHypertension in Melanesia. Journal of Human Genetics 58: 142-149.


38) Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M,AtakaY, Ishida T, Inaoka T, Iwamoto S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J.(2013) A functional SNP upstream ofthe beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations. International Journal ofObesity 37(9):1204-10


2012


37) Yamaguchi K, Watanabe C, Kawaguchi A, Sato T, Naka I, Shindo M, Moromizato K, Aoki K, Ishida H, Kimura R. (2012)Association of melanocortin 1 receptor gene (MC1R) polymorphisms with skin reflectance and freckles in Japanese. J HumGenet.57(11):700-8.


36) Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A, Takanashi M, Satake M, Nakajima K, Arase H,Tokunaga K, Patarapotikul J, Yabe T. (2012) Significant association of KIR2DL3-HLA-C1 combination with cerebral malariaand implications for co-evolution of KIR and HLA. PLoS Pathogens 8: e1002565.


35) Naka I, Ohashi J, Kimura R, Furusawa T, Yamauchi T, Nakazawa M, Natsuhara K, Ataka Y, Nishida N, Ishida T, Inaoka T,Matsumura Y, Ohtsuka R.(2012)DRD4 VNTR polymorphism in Oceanic populations. Anthropological Science 120(2): 151-155.


34) Kobayash K, Yuliwulandari R, Yanai H, Naka I, Lien L. T, Hang N. T. L, Hijikata M, Keicho N, Tokunaga K (2012)Association of TLR polymorphisms with development of tuberculosis in Indonesian females. Tissue Antigens 79, 190-197


2011


33) Kraisin S, Naka I, Patarapotikul J, Nantakomol D, Nuchnoi P, Hananantachai H, Tsuchiya N, Ohashi J (2011) Associationof ADAMTS13 polymorphism with cerebral malaria. Malaria Journal. 10:366 doi:10.1186/1475-2875-10-366.


32) Naka I, Nishida N, Ohashi J (2011) No evidence for strong recent positive selection favoring the 7 repeat allele of VNTR inthe DRD4 gene. PLoS ONE 6: e24410.


31) Myles S, Lea RA, Ohashi J, Chambers GK, Weiss JG, Hardouin E, Engelken J, Macartney-Coxson DP, Eccles DA, Naka I,Kimura R, Inaoka T, Matsumura Y, Stoneking M (2011) Testing the thrifty gene hypothesis: the Gly482Ser variant inPPARGC1A is associated with BMI in Tongans. BMC Medical Genetics. 12: 10.


30) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Nishida N, Eddie R, Ohtsuka R, Ohashi J(2011) The Serum Leptin Level and Body Mass Index in Melanesian and Micronesian Solomon Islanders: Focus on GeneticFactors and Urbanization. American Journal of Human Biology. 23: 435-444.


29) Ohashi J, Naka I, Tsuchiya N (2011) The impact of natural selection on an ABCC11 SNP determining earwax type.Molecular Biology and Evolution 28: 849-857.


2010


28) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ataka Y,NishidaN, Tsuchiya N, Ohtsuka R, Ohashi J (2010) The Q223R polymorphism in LEPR is associated with obesity in PacificIslanders. Human Genetics 127: 287-294.


27) Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M, SomeyaT,Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S,Naka I, Ohashi J, Kakita A,Takahashi H, Nawa H, Arinami T (2010) Brain Cannabinoid CB2 Receptor in Schizophrenia. Biological psychiatry 67: 974-982.


2009


26) Naka I, Patarapotikul J, Tokunaga K, Hananantachai H, Tsuchiya N, Ohashi J (2009) A replication study of theassociationbetween the IL12B promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population. MalariaJournal 8: 290.


25) Naka I, Nishida N, Patarapotikul J, Nuchnoi P, Tokunaga K, Hananantachai H, Tsuchiya N, Ohashi J (2009) Identificationof a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria. Malaria Journal 8:232.


24) Naka I, Patarapotikul J, Hananantachai H, Tokunaga K, Tsuchiya N, Ohashi J (2009) IFNGR1 polymorphisms in Thaimalaria patients. Infection, Genetics and Evolution 9: 1406-1409.


2008


23) Teeranaipong P, Ohashi J, Patarapotikul J, Kimura R, Nuchnoi P, Hananantachai H, NAKA I, Putaporntip C, Jongwutiwes S,Tokunaga K (2008) A Functional SNP in the CR1 Promoter Region Contributes to Protection against Cerebral Malaria. TheJournal of Infectious Diseases 198:1880-91


22) Nuchnoi P, Ohashi J, NAKA I, Nacapunchai D, Tokunaga K, Nishida N, Patarapotikul J (2008) LinkageDisequilibriumStructure of the 5q31-33 Region in a Thai Population. Journal of Human Genetics 53: 850-856.


21) NAKA I, Ohashi J, Nuchnoi P, Hananantachai H, Looareesuwan S, Tokunaga K ,Patarapotikul J. (2008) Lack of associationof the HbE variant with protection from cerebral malaria in Thailand. Biochemical Genetics 46(11-12):708-11.


20) Nuchnoi P, Ohashi J, Kimura R, Hananantachai H, NAKA I, Krudsood S, Looareesuwan S, Tokunaga K, Patarapotikul J(2008) Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand.Annals of Human Genetics 72: 27-336.


2007


19) Ohashi J, NAKA I, Kimura R, Natsuhara K, Yamauchi T, Furusawa T, Nakazawa N, Ataka Y, Patarapotikul J, Nuchnoi P,Tokunaga K, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R (2007) FTO polymorphisms in Oceanic populations. Journal ofHuman Genetics 52: 1031-1035.


18) NAKA I, Ohashi J, Patarapotikul J, Hananantachai H, Wilairatana P, Sornchai Looareesuwan S, Tokunaga K (2007) Thegenotypes of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria. Journal of HumanGenetics52: 476-479.


17) Hananantachai H, Patarapotikul J, Ohashi J, NAKA I, Krudsood S, Looareesuwan S, Tokunaga K (2007) Significantassociation between TNF-α (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand. TissueAntigens 69: 277-280.


2006


16) Ohashi J, NAKA I, Toyoda A, Takasu M, Tokunaga K, Ishida T, Sakaki Y, Hohjoh H (2006) Estimation of the species-specific mutation rates of the DRB1 locus in human and chimpanzee. Tissue Antigens 68: 427-431.


15) Ohashi J, NAKA I, Kimura R, Tokunaga K, Nakazawa M, Ataka Y, Ohtsuka R, Inaoka T, Matsumura Y (2006) HLA-DRB1polymorphism on Ha’ano Island of the Kingdom of Tonga. Anthropological Science 114: 193-198.


14) Ohashi J, NAKA I, Kimura R, Tokunaga K, Yamauchi T, Natsuhara K, Furusawa T, Yamamoto R, Nakazawa M, Ishida T,Ohtsuka R. (2006) Polymorphisms in the ABO blood group gene in three populations in New Georgia Islands, SolomonIslands. Journal of Human Genetics 51: 407-411.


13) Ohashi J, NAKA I, Tokunaga K, Inaoka T, Ataka Y, Nakazawa M, Matsumura Y, Ohtsuka R. (2006) Mitochondrial DNAvariation suggests extensive gene flow from Polynesian ancestors to indigenous Melanesians in the northwestern Bismarckarchipelago. American Journal of Physical Anthropology 130: 551-556.


2005


12) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Tangpukdee N, Looareesuwan S, Tokunaga K (2005) A functionalpolymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. Malaria Journal 4:38.


11) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan S, Clark AG, Tokunaga K (2005)Stronglinkage disequilibrium of a HbE variant with the (AT)9(T)5 repeat in the BP1 binding site upstream of the beta-globingene  inThai population. Journal of Human Genetics 50: 7-11.


10) Hananantachai H, Patarapotikul J, Ohashi J, NAKA I, Looareesuwan S, Tokunaga K (2005) Polymorphisms of HLA-B andHLA-DRB1 genes in Thai malaria patients. Japanese Journal of Infectious Diseases 58: 25-28.


2004


9) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan S, Clark AG, Tokunaga K (2004)Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. American Journal ofHumanGenetics 74: 1198-1208.


8) Ohashi J, NAKA I, Ohtsuka R, Inaoka T, Ataka Y, Nakazawa M, Tokunaga K, Matsumura Y (2004) Molecular polymorphismof ABO blood group gene in Austronesian and Non-Austronesian populations in Oceania. Tissue Antigens 63:355-361.


2003


7) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2003) A single nucleotide substitutionfrom C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand. Genes andImmunity 4: 528-531.


6) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, NAKA I, Looareesuwan S, Tokunaga K (2003) CD36 polymorphismisassociated with protection from cerebral malaria. American Journal of Human Genetics 72: 364-374.


2002


5) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, NAKA I, Looareesuwan S, Tokunaga K (2002) Absence of Associationbetween the Fcg receptor IIIA-176F/V Polymorphism and the Severity of Malaria in Thai. Japanese Journal of InfectiousDiseases 55: 167-169.


4) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, NAKA I, Looareesuwan S, Tokunaga K (2002) Fcg receptor IIA and IIIBpolymorphisms are associated with susceptibility to cerebral malaria. Parasitology International 51: 361-366.


3) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2002) Significant association of longerforms of CCTTT microsatellite repeat in inducible nitric oxide synthase (iNOS) promoter with severe malaria in Thailand.Journal of Infectious Diseases 186: 578-581.


2001


2) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2001) Absence of associationbetweenthe allele coding methionine at position 29 in the N-terminal domain of ICAM-1 (ICAM-1Kilifi) and severe malaria inthenorthwest of Thailand. Japanese Journal of Infectious Diseases 54: 114-116.


1) Hananantachai H, Patarapotikul J, Looareesuwan S, Ohashi J, NAKA I, Tokunaga K (2001) Lack of association of -308A/GTNFA promoter and 196R/M TNFR2 polymorphisms with disease severity in Thai adult malaria patients. American Journal ofMedical Genetics 102: 391-392.




総説・本


中 伊津美 2014 ADRB2肥満関連多型の起源 医学のあゆみ. Vol 249, No 11, pp1217-1219


中 伊津美 2014 オセアニア集団の肥満とADRB2遺伝子多型-ゲノム人類学的視点から. 医学のあゆみ. Vol 248, No 3, pp227-229






中伊津美、大橋順 (2015) 東京大学生命科学シンポジウム 優秀ポスター賞 

オセアニア集団における ADRB2 遺伝子多型と肥満との関連 -肥満リスクアリルはどこから来たのか-