Department of Biological Sciences Graduate School of Science The University of Tokyo
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Laboratory of Embryogenesis


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Hiroyuki TAKEDA (Professor)
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Sumito KOSHIDA (Associate Professor)
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Selected publications

Shimada, A., Yabusaki, M., Niwa, H., Yokoi, H., Hatta, K., Kobayashi, D. and Takeda, H. (2008) Maternal-zygotic medaka mutants for fgfr1 reveal its essential role in the migration of the axial mesoderm but not the lateral mesoderm. Development 135, 281-90.

Yokoi, H., Shimada, A., Carl, M., Takashima, S., Kobayashi, D., Narita, T., Jindo, T., Kimura, T., Kitagawa, T., Kage, T., Sawada, A., Naruse, K., Asakawa, S., Shimizu, N., Mitani, H., Shima, A., Tsutsumi, M., Hori, H., Wittbrodt, J., Saga, Y., Ishikawa, Y., Araki, K. and Takeda, H. (2007) Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships. Dev Biol 304, 326-37.

Kasahara, M., Naruse, K., Sasaki, S., Nakatani, Y., Qu, W., Ahsan, B., Yamada, T., Nagayasu, Y., Doi, K., Kasai, Y., Jindo, T., Kobayashi, D., Shimada, A., Toyoda, A., Kuroki, Y., Fujiyama, A., Sasaki, T., Shimizu, A., Asakawa, S., Shimizu, N., Hashimoto, S., Yang, J., Lee, Y., Matsushima, K., Sugano, S., Sakaizumi, M., Narita, T., Ohishi, K., Haga, S., Ohta, F., Nomoto, H., Nogata, K., Morishita, T., Endo, T., Shin, I. T., Takeda, H., Morishita, S. and Kohara, Y. (2007) The medaka draft genome and insights into vertebrate genome evolution. Nature 447, 714-9.

Horikawa, K., Ishimatsu, K., Yoshimoto, E., Kondo, S. and Takeda, H. (2006) Noise-resistant and synchronized oscillation of the segmentation clock. Nature 441, 719-23.



Akanuma, T., Koshida, S., Kawamura, A., Kishimoto, Y., and Takada, S. (2007) Paf1 complex homologs are required for Notch-regulated transcription during somite segmentation. EMBO reports, 8(9):858-863.

Kawamura A, Koshida S, Hijikata H, Ohbayashi A, Kondoh H, and Takada S. (2005) Groucho-associated transcriptional repressor Ripply1 is required for proper transition from the presomitic mesoderm to somites. Developmental Cell, 9(6):735-744.

Kawamura A1, Koshida S1, Hijikata H, Sakaguchi T, Kondoh H, and Takada S. (1 These authors contributed equally to this work.) (2005) Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Genes & Development, 19 (10): 1156-1161.

Koshida S, Kishimoto Y, Ustumi H, Shimizu T, Furutani-Seiki M, Kondoh H, and Takada S. (2005) Integrin alpha5-dependent Fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. Developmental Cell, 8(4):587-598.

Koshida, S., Shinya, M., Nikaido, M., Ueno, N., Schulte-Merker, S., Kuroiwa, A. and Takeda, H. (2002) Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafish. Developmental Biology, 244(1): 9-20, 2002.


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Department of Biological Science, Graduate School of Science,The University of Tokyo