Department of Biological Sciences Graduate School of Science The University of Tokyo
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Laboratory of Molecular Cognitive Sciences


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Shoichi ISHIURA (Professor)
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Selected publications

Koike H., Tomioka S., Sorimachi H., Saido T.C., Maruyama K., Okuyama A., Fujisawa-Sehara A., Ohno S., Suzuki K. and Ishiura, S. (1999) Membrane-anchored metallopeptidase MDC9 has an α-secretase activity responsible for processing the amyloid precursor protein. Biochem.J. 343: 371-375.

Kino Y., Oma Y., Sasagawa N. and Ishiura, S. (2004) Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats. Human Mol.Genet. 13: 495-507.

Oma Y., Kino Y., Sasagawa N. and Ishiura S. (2004) Intracellular localization of homopolymeric amino acid-containing proteins expressed in mammalian cells. J.Biol.Chem. 279: 21217-21222.

Asai M., Hattori C., Iwata N., Saido S.C., Sasagaw, N., Szabo B., Hashimoto Y., Maruyama K., Tanuma S., Kiso Y. and Ishiura, S. (2006) A novel β–secretase inhibitor KMI-429 reduces amyloid β peptide (Aβ) production in amyloid precursor protein (APP) transgenic and wild-type mice. J.Neurochem. 96: 533-540.

Uchio N., Oma Y., Toriumi K., Sasagawa N., Tanida I., Fujita E., Kouroku Y., Kuroda R., Momoi T. and Ishiura, S. (2007) Endoplasmic reticulum stress caused by aggregate-prone proteins containing homopolymeric amino acids. FEBS J. 274,: 5619-5627.

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Department of Biological Science, Graduate School of Science,The University of Tokyo