Department of Biological Sciences Graduate School of Science The University of Tokyo
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Laboratory of Misaki Marine
Biological Station


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Koji AKASAKA (Professor)
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Kaoru KUBOKAWA (Professor)
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Mariko KONDO (Associate Professor)
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Manabu YOSHIDA (Lecturer)
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Selected publications

Yajima M., Kiyomoto M. and Akasaka K. (2007) Ars insulator protects transgenes from long-term silencing in sea urchin larva. Dev Genes Evo. 217: 331-336.

Watanabe S., Watanabe S., Sakamoto N., Sato M. and Koji Akasaka (2006) Functional Analysis of the Sea Urchin-Derived Arylsulfatase (Ars)-Element in Mammalian Cells. Genes to Cell 11:1009-1021.

Fuchikami T., Mitsunaga-Nakatsubo K., Amemiya S., Hosomi T. and Akasaka K. (2002) T-brain homolog (HpTb) is involved in the archenteron induction signals of micromere descendant cells in the sea urchin embryo. Development, 129: 5205-5216.

Kiyama T., Sasai K., Takata K., Mitsunaga-Nakatsubo K., Shimada H. and Akasaka K. (2000) CAAT sites are required for the activation of the H. pulcherrimus Ars gene by Otx. Dev. Genes and Evo., 210: 583-590.



Yajima M., Kiyomoto M. and Akasaka K. (2007) Ars insulator protects transgenes from long-term silencing in sea urchin larva. Dev Genes Evo. 217: 331-336.

Kondo M., Hornung U., Nanda I., Imai S., Sasaki T., Shimizu A., Asakawa S., Hori H., Schmid M., Shimizu N., Schartl M. (2006) Genomic organization of the sex-determining and adjacent regions of the sex chromosomes of medaka. Genome Research; 16(7): 815-826

Kondo M., Nanda I., Hornung U., Schmid M., Schartl M. (2004) Evolutionary origin of the medaka Y-chromosome. Current Biology; 14: 1664-1669

Kondo M., Nanda I., Hornung U., Asakawa S., Shimizu N., Mitani H., Schmid M., Shima A., Schartl M. (2003) Absence of the candidate male sex determining gene DMRT1bY of medaka in other fish species. Current Biology; 13 (5): 416-420

*Nanda I., *Kondo M., *Hornung U., Asakawa S., Winkler C., Shimizu A., Shan Z., Haaf T., Shimizu N., Shima A., Schmid M., Schartl M. (*: equal contribution) (2002) A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes. Proc Natl Acad Sci U S A.; 99 (18): 11778-11783.

Kondo M., Froschauer A., Kitano A., Nanda I., Hornung U., Volff JN., Asakawa S., Mitani H., Naruse K., Tanaka M., Schmid M., Shimizu N., Schartl M., Shima A. (2002) Molecular cloning and characterization of DMRT genes from the medaka Oryzias latipes and the platyfish Xiphophorus maculatus. Gene 295 (2): 213-222.



Kawano, N. and Yoshida, M. (2007) Seminal vesicle protein, secretion 2 (SVS2) controls mouse sperm fertility. Biol. Reprod., 76, 353-361.

Matsu-ura, T., Michikawa, T., Inoue, T., Miyawaki, A., Yoshida, M., and Mikoshiba, K. (2006) Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells. J. Cell Biol., 173, 755-765

Fukami, K., Yoshida, M., Inoue, T., Kurokawa, M., Fissore, R., Yoshida, N., Mikoshiba, K., and Takenawa, T. (2003) Phospholipase Cδ4 is required for Ca2+-mobilization essential for acrosome reaction in sperm. J. Cell Biol., 161, 79-88.

Yoshida, M., Ishikawa, M., Izumi, H., DeSantis, R., and Morisawa, M. (2003) Store operated calcium channel regulates chemotactic behavior of ascidian sperm. Proc. Natl. Acad. Sci. USA, 100, 149-154

Yoshida, M., Murata, M., Inaba, K, and Morisawa, M. (2002) A chemoattractant for ascidian spermatozoa is a sulfated steroid. Proc. Natl. Acad. Sci. USA, 99, 14831-14836.


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Department of Biological Science, Graduate School of Science,The University of Tokyo